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Abstract
Alzheimer disease is neurodegenerative disease which has no exact cure. In this study the anticholinesterase activity of sunflower honey samples produced in four regions of Adana city and various wholesalers through Turkey was screened. The anticholinesterase activity was performed according to the Elman's method against acetylcholinesterase and butyrylcholinesterase which are the chief enzymes against Alzheimer disease. All sunflower honey samples exhibited anticholinesterase activity. The honey samples produced under control dose dependently inhibited acetylcholinesterase and butyrylcholinesterase in the range of 28.33-34.86% and 27.57-39.75% at 10 mg/mL, respectively. The sunflower honey samples from various wholesalers, however, served 14.77-21.36 and 14.18-23.64% at the same concentration, respectively. The anticholinesterase activity of processed sunflower honey samples exhibited less or no activity when compared to those of produced under control ones. It was concluded that the filtering process and honey sample's shelf life might affect the lesser enzyme inhibitory activity. Moreover, the possibilities such as storage and processing of honey are among the factors that affect the composition of honey. Consuming or using honey freshly, therefore, advised to be benefited from the anticholinesterase property of honey.
