Current Language EN
English English Türkçe Türkçe Español Español Português Português Pусский Pусский Filipino Filipino Tiếng Việt Tiếng Việt हिन्दी हिन्दी العربية العربية বাংলা বাংলা Deutsch Deutsch 中文 中文
Research Article

Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities

1258 reads
Yusuf Sıcak
J Ong Chem Res, 2018, 3 (2), 71-74, DOI: https://doi.org/10.5281/zenodo.2553565, ISSN 2651-4338
Verified on SciChain · token #122 of SciMatic Articles (ERC-1155, 1,000,000 tokens)
Contract 0x0E596B4b…F05eF8 · mint transaction · verify the record
Proof of record · recorded 2026-10-17 · anchored on SciChain · Verify (opens in a new tab) · record

Abstract

Hydrazones were considered as significant substrates in drug discovery process. Therefore, a series of some new 1-(4-(1-(2-(4-substitutedphenyl)hydrazono)ethyl)phenyl)-3-(4-nitrophenyl)urea derivatives (2-8) were synthesized as potential urease inhibitory agents. The synthesized compounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis (C, H, N). All compounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds, 8, 7, 6, and 4 showed excellent activities (IC50) i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and 22.95±0.47 µM, respectively. This study has culminated in the identification of some compounds which can serve as leads for new potent urease inhibitors.

Keywords organic synthesis Urease inhibition activity Hydrazone Enzyme inhibitors Urea
Author 1
View Publication Certificate Order a Printed Certificate For this article's authors: $50.00 ($35.00 to the Philippines), shipping included. View PDF Cite This Article Back to Archives

The team behind this paper

1 author.

This paper Yusuf Sıcak — corresponding author YS Yusuf Sıcak ✉

1 of them has not recorded an affiliation.

Readership

476 reads over 34 months.

February 2024 November 2026

Related work on SciMatic

Closest of 3 articles sharing keywords with this one. A rarer shared keyword counts for more than a common one.

On SciChain

This article is token #122 of SciMatic Articles (ERC-1155): 1,000,000 tokens, minted once, never more. The chain also stores a fingerprint (SHA-256) of the article's record, so anyone can check that it has not been altered.

HolderWalletTokens
SciMatic 0xc35709…277732 100,000 (10%)
Yusuf Sıcak 0xaCF039…2E49f4 900,000 (90%)
Content hash 0x507469f4de9c2be258be26c916c9729b5e5044dd5bbb2289472b41a7f1cf45d6
View on the explorer Verify the record Mint transaction

Bibliographic Information

Yusuf Sıcak (2018). Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities, Journal of Ongoing Chemical Research, 3(2): 71-74
Bibtex Citation
@article{yusuf_sıcak2018jocr,
author = {Yusuf Sıcak},
title = {Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities},
journal = {Journal of Ongoing Chemical Research},
year = {2018},
volume = {3},
number = {2},
pages = {71-74},
doi = {10.5281/zenodo.2553565},
url = {https://scimatic.org/show_manuscript/122}
}
APA Citation
Sıcak, Y., (2018). Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities. Journal of Ongoing Chemical Research, 3(2), 71-74. https://doi.org/10.5281/zenodo.2553565

Author Information

  • To change your profile photo, login to scimatic.org, go to your profile and change the photo.
  • Any photo that shows your face will do: we crop it to your head and shoulders and give it a plain background automatically.
  • To sign in, go to Sign in and enter the e-mail address registered with the article: we e-mail you a one-time sign-in link (there is no password).
  • In case of any other problem, contact your editor directly or write to us at info @ scimatic.org