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Research Article

Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities

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Yusuf Sıcak
J Ong Chem Res, 2018, 3 (2), 71-74, DOI: https://doi.org/10.5281/zenodo.2553565, ISSN 2651-4338
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Abstract

Hydrazones were considered as significant substrates in drug discovery process. Therefore, a series of some new 1-(4-(1-(2-(4-substitutedphenyl)hydrazono)ethyl)phenyl)-3-(4-nitrophenyl)urea derivatives (2-8) were synthesized as potential urease inhibitory agents. The synthesized compounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis (C, H, N). All compounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds, 8, 7, 6, and 4 showed excellent activities (IC50) i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and 22.95±0.47 µM, respectively. This study has culminated in the identification of some compounds which can serve as leads for new potent urease inhibitors.

Keywords organic synthesis Urease inhibition activity Hydrazone Enzyme inhibitors Urea
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The team behind this paper

1 author.

This paper Yusuf Sıcak — corresponding author YS Yusuf Sıcak ✉

1 of them has not recorded an affiliation.

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458 reads over 33 months.

February 2024 October 2026

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Bibliographic Information

Yusuf Sıcak (2018). Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities, Journal of Ongoing Chemical Research, 3(2): 71-74
Bibtex Citation
@article{yusuf_sıcak2018jocr,
author = {Yusuf Sıcak},
title = {Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities},
journal = {Journal of Ongoing Chemical Research},
year = {2018},
volume = {3},
number = {2},
pages = {71-74},
doi = {10.5281/zenodo.2553565},
url = {https://scimatic.org/show_manuscript/122}
}
APA Citation
Sıcak, Y., (2018). Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities. Journal of Ongoing Chemical Research, 3(2), 71-74. https://doi.org/10.5281/zenodo.2553565

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