Research Article

SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

843 reads

Yusuf Sıcak , Said Nadeem , Bedriye Seda Kurşun Aktar , Emine Elçin Oruç Emre , Mehmet Öztürk , Ayşegül Karaküçük İyidoğan , Mehmet Ali Özler , İbrahim Demirtaş

J Ong Chem Res, 2017, 3 (1), 32-49, doi: 10.5281/zenodo.3768580, ISSN 2651-4338

Abstract

A series of some pyrazolo derivatives (1-2)(a-f) were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated. Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities (IC50) i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 μM, respectively. According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50.

Blockchain Confirmation

Token ID:

Hash:

If you want to upload this article to SciMatic Hybrid Blockchain, install MetaMask extension to your web browser, create a wallet and buy SCI coins at SciMatic using credit or contact your country coordinator.

One article costs 10 SCI coins to be in the Blockchain. Buy SCI Coins

Bibliographic Information

Yusuf Sıcak, Said Nadeem, Bedriye Seda Kurşun Aktar, Emine Elçin Oruç Emre, Mehmet Öztürk, Ayşegül Karaküçük İyidoğan, Mehmet Ali Özler, İbrahim Demirtaş, (2017). SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES, Journal of Ongoing Chemical Research, 3(1): 32-49

Bibtex Citation


                        
            @article{said_nadeem2017jocr,

                author       = {Yusuf Sıcak and Said Nadeem and Bedriye Seda Kurşun Aktar and Emine Elçin Oruç Emre and Mehmet Öztürk and Ayşegül Karaküçük İyidoğan and Mehmet Ali Özler and İbrahim Demirtaş},

                title        = {SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES},

                journal      = {Journal of Ongoing Chemical Research},

                year         = {2017},

                volume       = {3},

                number       = {1},

                pages        = {32-49},

                doi          = {10.5281/zenodo.3768580},

                url          = {https://scimatic.org/show_manuscript/30}

              }

APA Citation

Sıcak, Y., Nadeem, S., Aktar, B.S.K., Emre, E.E.O., Öztürk, M., İyidoğan, A.K., Özler, M.A., Demirtaş, İ., (2017). SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES. Journal of Ongoing Chemical Research, 3(1), 32-49. https://doi.org/10.5281/zenodo.3768580

Author Information

To change your profile photo, login to scimatic.org, go to your profile and change the photo.
Provide a face photo, and not full body.
It is better to remove the background from your photo. Go to Remove Background and then upload to profile
If you are unable to login, go to Reset My Password provide your email registered with the article and get new password.
In case of any other problem, contact your editor directly or write to us at info @ scimatic.org

SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

Abstract

Blockchain Confirmation

Bibliographic Information

Author Information

About

Services

Legal

License

SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

Abstract

Share This Paper

Blockchain Confirmation

Bibliographic Information

Author Information

About

Services

Legal

License