SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES
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Yusuf Sıcak,
Said Nadeem,
Bedriye Seda Kurşun Aktar,
Emine Elçin Oruç Emre,
Mehmet Öztürk,
Ayşegül Karaküçük İyidoğan,
Mehmet Ali Özler,
İbrahim Demirtaş,
J Ong Chem Res, 2017, 3 (1), 32-49, doi: 10.5281/zenodo.3768580, ISSN 2651-4338
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Abstract:
A series of some pyrazolo derivatives (1-2)(a-f) were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated. Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities (IC50) i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 μM, respectively. According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50.
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Yusuf Sıcak, Said Nadeem, Bedriye Seda Kurşun Aktar, Emine Elçin Oruç Emre, Mehmet Öztürk, Ayşegül Karaküçük İyidoğan, Mehmet Ali Özler, İbrahim Demirtaş, (2017). SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES, Journal of Ongoing Chemical Research, 3(1): 32-49
@article{said_nadeem2017jocr,
author = {Yusuf Sıcak and Said Nadeem and Bedriye Seda Kurşun Aktar and Emine Elçin Oruç Emre and Mehmet Öztürk and Ayşegül Karaküçük İyidoğan and Mehmet Ali Özler and İbrahim Demirtaş},
title = {SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES},
journal = {Journal of Ongoing Chemical Research},
year = {2017},
volume = {3},
number = {1},
pages = {32-49},
doi = {10.5281/zenodo.3768580},
url = {https://scimatic.org/show_manuscript/30}
}
