Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials

Dr. Hayat Ullah; Fahad Khan; Imad Uddin; Fazal Rahim; Muhammad Taha; Khalid Zaman; Aftab Ahmad Khan; Fawad Ahmad; Zia Ur Rehman; Fazal Suhrab Gul; Mehran; Nisar Ahmad; Mushtaq Ahmad; Muhammad Imran Fakhri; Khalid Mohammad Khan

Research Article

Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials

1588

reads

Dr. Hayat Ullah, Fahad Khan, Imad Uddin, Fazal Rahim, Muhammad Taha, Khalid Zaman, Aftab Ahmad Khan, Fawad Ahmad, Zia Ur Rehman, Fazal Suhrab Gul, Mehran, Nisar Ahmad, Mushtaq Ahmad, Muhammad Imran Fakhri, Khalid Mohammad Khan,

J Ong Chem Res, 2020, 5 (1), 1-6, doi: 10.5281/zenodo.3703324, ISSN 2651-4338

Abstract:

Prostate cancer is perhaps the most dominant cancer in men. The increased resistance to therapeutic agents and deficiency of targeted therapy for prostate cancer cells offer motivation to find new scaffolds for the treatment. The current study investigates substituted biscoumarin analogs (1-19) anticancer activity in the prostate cancer (PC3) cell line and its antioxidant potential. Out of these nineteen analogs, the compounds 1, 8, 9, 10, 12, 14, 16, 18 and 19 showed good PC3 cell line inhibitory potential when compared with the standard doxorubicin. Compounds 1-19 were also checked for DPPH radical scavenging potential. Compounds 2, 5, and 17 showed good potential. All analogs were also evaluated for superoxide anion scavenging activity and found to be inactive. The docking analysis shows that the biscoumarin is an anti-cancer ligand and has the ability to inhibit the activity of the human histone acetyltransferase. Overall this study has contributed for anticancer and antioxidant agents.

Keywords: molecular docking, biscoumarin, PC3 cell line, DPPH radical, Superoxide Anion Scavenging,

PDF

Back

Blockchain confirmation

Token ID: Hash:

If you want to upload this article to SciMatic Hybrid Blockchain, install MetaMask extension to your web browser, create a wallet and buy SCI coins at SciMatic using credit or contact your country coordintor

One article cost 10 SCI coins to be in the Blockchain. Buy SCI Coins

Bibliographic Information

Dr. Hayat Ullah, Fahad Khan, Imad Uddin, Fazal Rahim, Muhammad Taha, Khalid Zaman, Aftab Ahmad Khan, Fawad Ahmad, Zia Ur Rehman, Fazal Suhrab Gul, Mehran, Nisar Ahmad, Mushtaq Ahmad, Muhammad Imran Fakhri, Khalid Mohammad Khan, (2020). Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials, Journal of Ongoing Chemical Research, 5(1): 1-6

Bibtex Citation


                        
            @article{dr._hayat_ullah2020jocr,

                author       = {Dr. Hayat Ullah and Fahad Khan and Imad Uddin and Fazal Rahim and Muhammad Taha and Khalid Zaman and Aftab Ahmad Khan and Fawad Ahmad and Zia Ur Rehman and Fazal Suhrab Gul and Mehran and Nisar Ahmad and Mushtaq Ahmad and Muhammad Imran Fakhri and Khalid Mohammad Khan},

                title        = {Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials},

                journal      = {Journal of Ongoing Chemical Research},

                year         = {2020},

                volume       = {5},

                number       = {1},

                pages        = {1-6},

                doi          = {10.5281/zenodo.3703324},

                url          = {https://scimatic.org/show_manuscript/177}

              }

APA Citation

Ullah, D.H., Khan, F., Uddin, I., Rahim, F., Taha, M., Zaman, K., Khan, A.A., Ahmad, F., Rehman, Z.U., Gul, F.S., Mehran, , Ahmad, N., Ahmad, M., Fakhri, M.I., Khan, K.M., (2020). Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials. Journal of Ongoing Chemical Research, 5(1), 1-6. https://doi.org/10.5281/zenodo.3703324

To change your profile photo, login to scimatic.org, go to your profile and change the photo.
Provide a face photo, and not full body.
It is better to remove the background from your photo. Go to Remove Background and then upload to profile
If you are unable to login, go to Reset My Password provide your email registerd with the article and get new password.
In case of any other problem, contact your editor directly or write to us at info @ scimatic.org

Certificate of Publishing

This is to certify that the manuscript entitled

Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials

is published by

Dr. Hayat Ullah