Research Article

Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials

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Hayat Ullah, Fahad Khan, Imad Uddin, Fazal Rahim, Muhammad Taha, Khalid Zaman, Aftab Ahmad Khan, Fawad Ahmad, Zia Ur Rehman, Fazal Suhrab Gul, Mehran, Nisar Ahmad, Mushtaq Ahmad, Muhammad Imran Fakhri, Khalid Mohammad Khan,
J Ong Chem Res, 2020, 5 (1), 1-6, doi: 10.5281/zenodo.3703324, ISSN 2651-4338
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Abstract:

Prostate cancer is perhaps the most dominant cancer in men. The increased resistance to therapeutic agents and deficiency of targeted therapy for prostate cancer cells offer motivation to find new scaffolds for the treatment. The current study investigates substituted biscoumarin analogs (1-19) anticancer activity in the prostate cancer (PC3) cell line and its antioxidant potential. Out of these nineteen analogs, the compounds 1, 8, 9, 10, 12, 14, 16, 18 and 19 showed good PC3 cell line inhibitory potential when compared with the standard doxorubicin. Compounds 1-19 were also checked for DPPH radical scavenging potential. Compounds 2, 5, and 17 showed good potential. All analogs were also evaluated for superoxide anion scavenging activity and found to be inactive. The docking analysis shows that the biscoumarin is an anti-cancer ligand and has the ability to inhibit the activity of the human histone acetyltransferase. Overall this study has contributed for anticancer and antioxidant agents.

Keywords: molecular docking, biscoumarin, PC3 cell line, DPPH radical, Superoxide Anion Scavenging,
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Bibliographic Information

Hayat Ullah, Fahad Khan, Imad Uddin, Fazal Rahim, Muhammad Taha, Khalid Zaman, Aftab Ahmad Khan, Fawad Ahmad, Zia Ur Rehman, Fazal Suhrab Gul, Mehran, Nisar Ahmad, Mushtaq Ahmad, Muhammad Imran Fakhri, Khalid Mohammad Khan, (2020). Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials, Journal of Ongoing Chemical Research, 5(1): 1-6

Bibtex Citation
@article{hayat_ullah2020jocr,
author = {Hayat Ullah and Fahad Khan and Imad Uddin and Fazal Rahim and Muhammad Taha and Khalid Zaman and Aftab Ahmad Khan and Fawad Ahmad and Zia Ur Rehman and Fazal Suhrab Gul and Mehran and Nisar Ahmad and Mushtaq Ahmad and Muhammad Imran Fakhri and Khalid Mohammad Khan},
title = {Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials},
journal = {Journal of Ongoing Chemical Research},
year = {2020},
volume = {5},
number = {1},
pages = {1-6},
doi = {10.5281/zenodo.3703324},
url = {https://scimatic.org/show_manuscript/177}
}
APA Citation
Ullah, H., Khan, F., Uddin, I., Rahim, F., Taha, M., Zaman, K., Khan, A.A., Ahmad, F., Rehman, Z.U., Gul, F.S., Mehran, , Ahmad, N., Ahmad, M., Fakhri, M.I., Khan, K.M., (2020). Synthetic Biscoumarin Analogs: Their PC3 Cell Line and Antioxidant Inhibitory Potentials. Journal of Ongoing Chemical Research, 5(1), 1-6. https://doi.org/10.5281/zenodo.3703324