Research article
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The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Nature, vol. 318, no. 6046, pp. –, 1970
Abstract
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leuk …
Keywords
- National Center for Biotechnology Information
- NCBI
- NLM
- MEDLINE
- genetic
- Mice
- gene expression regulation
- animals
- pubmed abstract
- nih
- national institutes of health
- national library of medicine
- research support
- non-u.s. gov't
- u.s. gov't
- P.H.S.
- DNA
- Genes
- enhancer elements
- genetic*
- recombination
- transcription
- cell differentiation
- proto-oncogene proteins / genetics*
- recombinant
- oncogenes*
- pmid:3906410
- doi:10.1038/318533a0
- j m adams
- a w harris
- r l brinster
- b-lymphocytes / pathology
- regulator*
- immunoglobulins / genetics*
- lymphoma / genetics*
How to cite
Adams JM; Harris AW; Pinkert CA; Corcoran LM; Alexander WS; Cory S; Palmiter RD; Brinster RL. (1970). The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature, 318(6046), –. http://www.ncbi.nlm.nih.gov/pubmed/3906410
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