The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Abstract
Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leuk …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
gene expression regulation
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
DNA
Genes
enhancer elements
genetic*
recombination
transcription
cell differentiation
proto-oncogene proteins / genetics*
recombinant
oncogenes*
pmid:3906410
doi:10.1038/318533a0
j m adams
a w harris
r l brinster
b-lymphocytes / pathology
regulator*
immunoglobulins / genetics*
lymphoma / genetics*
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268545
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