The diploid genome sequence of an Asian individual
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The diploid genome sequence of an Asian individual

Wang J;Wang W;Li R;Li Y;Tian G;Goodman L;Fan W;Zhang J;Li J;Zhang J;Guo Y;Feng B;Li H;Lu Y;Fang X;Liang H;Du Z;Li D;Zhao Y;Hu Y;Yang Z;Zheng H;Hellmann I;Inouye M;Pool J;Yi X;Zhao J;Duan J;Zhou Y;Qin J;Ma L;Li G;Yang Z;Zhang G;Yang B;Yu C;Liang F;Li W;Li S;Li D;Ni P;Ruan J;Li Q;Zhu H;Liu D;Lu Z;Li N;Guo G;Zhang J;Ye J;Fang L;Hao Q;Chen Q;Liang Y;Su Y;San A;Ping C;Yang S;Chen F;Li L;Zhou K;Zheng H;Ren Y;Yang L;Gao Y;Yang G;Li Z;Feng X;Kristiansen K;Wong GK;Nielsen R;Durbin R;Bolund L;Zhang X;Li S;Yang H;Wang J;;
Nature 2008 Vol. 456 pp. -
304
j2008naturethe

Abstract

Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We aligned the short reads onto the NCBI human reference genome to 99.97% coverage, and guided by the reference genome, we us …

Keywords

Internet databases National Center for Biotechnology Information NCBI NLM MEDLINE genetic animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't sequence alignment Comparative Study genome phenotype human / genetics* sensitivity and specificity Polymorphism genomics* jun wang consensus sequence alleles single nucleotide / genetics diploidy* pmid:18987735 pmc2716080 doi:10.1038/nature07484 wei wang jian wang asian continental ancestry group / genetics* genetic predisposition to disease / genetics haplotypes / genetics pan troglodytes / genetics

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