National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine logistic models research support non-u.s. gov't adult female male aged middle aged Randomized Controlled Trial Multicenter Study sensitivity and specificity Bacteria / genetics anti-bacterial agents / therapeutic use bacterial infections / microbiology multivariate analysis bacterial infections / diagnosis* bacteria / isolation & purification anti-infective agents bacterial infections / economics respiratory tract infections / drug therapy* respiratory tract infections / microbiology bacterial infections / drug therapy viruses / isolation & purification virus diseases / drug therapy polymerase chain reaction* virus diseases / virology respiratory tract infections / diagnosis* viruses / genetics marc j m bonten pmid:16231254 pmc7107964 doi:10.1086/497134 jan jelrik oosterheert anton m van loon respiratory tract infections / economics virus diseases / diagnosis* virus diseases / economics