C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue
Abstract
Knockout of C/EBPalpha causes a severe loss of liver function and, subsequently, neonatal lethality in mice. By using a gene replacement approach, we generated a new C/EBPalpha-null mouse strain in which C/EBPbeta, in addition to its own expression, substituted for C/EBPalpha expression in tissues. …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
Inbred C57BL
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
female
male
Comparative Study
genetic*
CCAAT-Enhancer-Binding Proteins
Genotype
pmid:10982846
PMC86283
doi:10.1128/mcb.20.19.7292-7299.2000
S S Chen
J F Chen
Y H Lee
Adipose Tissue / metabolism*
Blood Glucose / metabolism
Chimera
Complement Factor D
Crosses
Cysteine Dioxygenase
DNA-Binding Proteins / biosynthesis
DNA-Binding Proteins / deficiency
DNA-Binding Proteins / genetics*
DNA-Binding Proteins / physiology*
Dioxygenases*
Fertility
Gene Expression Regulation*
Leptin / biosynthesis
Leptin / genetics
Lipid Metabolism
Liver / metabolism*
Liver Failure / genetics*
Liver Failure / metabolism
Liver Failure / prevention & control
Knockout
Nuclear Proteins / biosynthesis
Nuclear Proteins / deficiency
Nuclear Proteins / genetics*
Nuclear Proteins / physiology*
Organ Specificity
Oxygenases / biosynthesis
Oxygenases / genetics
Promoter Regions
Messenger / biosynthesis
Messenger / genetics
Recombinant Fusion Proteins / biosynthesis
Recombinant Fusion Proteins / physiology
Serine Endopeptidases / biosynthesis
Serine Endopeptidases / genetics
Transferrin / biosynthesis
Transferrin / genetics
Citation
ID:
111385
References
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