Research Article

Synthesis and structural characterization of mono acid-type partial cone conformation azocalix[4]arene

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Serkan Elçin
J Ong Chem Res, 2022, 6 (1), 24-28, doi: 10.5281/zenodo.6526076, ISSN 2651-4338
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Abstract:

The synthesis of chromogenic mono acid-type azocalix[4]arene derivatives is described in this study. From p-tert-butylcalix[4]arene, which was made with p-tert-butylphenol as a starting material, a new family of azocalix[4]arene monocarboxylic acid derivatives (5a-d) were synthesized. Four azocalix[4]arenes (3a-d) were produced by attaching 4-methoxy-, 4-ethyl-, 4-chloro-, and 4-bromoaniline to 25,26,27,28-tetrahydroxycalix[4]arene through a diazo-coupling reaction. To obtain partial cone conformation acid derivatives, their mono ester units were synthesized with ethyl bromoacetate and hydrolyzed in a basic media (5a-d). Products were obtained in suitable (79-92 %) yields, with 25-(carboxymethoxy)-26,27,28-trihydroxy-5,11,17,23-tetra(4-methoxyphenyl)azocalix[4]arene (5a) being the product with the highest yield (92 %). FT-IR and 1H-NMR spectroscopy approaches, as well as elemental analysis techniques, were used to elucidated the synthesized products.

Keywords: structural properties, Azocalix[4]arene, Calix[n]arene, Diazo-coupling reaction, partial cone conformation,
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Bibliographic Information

Serkan Elçin (2022). Synthesis and structural characterization of mono acid-type partial cone conformation azocalix[4]arene, Journal of Ongoing Chemical Research, 6(1): 24-28

Bibtex Citation
@article{serkan_elçin2022jocr,
author = {Serkan Elçin},
title = {Synthesis and structural characterization of mono acid-type partial cone conformation azocalix[4]arene},
journal = {Journal of Ongoing Chemical Research},
year = {2022},
volume = {6},
number = {1},
pages = {24-28},
doi = {10.5281/zenodo.6526076},
url = {https://scimatic.org/show_manuscript/266}
}
APA Citation
Elçin, S., (2022). Synthesis and structural characterization of mono acid-type partial cone conformation azocalix[4]arene. Journal of Ongoing Chemical Research, 6(1), 24-28. https://doi.org/10.5281/zenodo.6526076