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Abstract
Academic preparedness among senior high school students is hampered by their lack of 21st-century abilities, especially in science education. This study investigated how inquiry-based learning (IBL) mediated the relationship between academic adaptability and scientific 21st- century abilities. Using a non-experimental quantitative research design, the study surveyed 200 senior high school students selected through random convenience sampling; it was revealed that Inquiry-based learning partially mediates the link between adaptability and scientific 21st-century abilities of senior high school students, affirming the Social Cognitive Theory. It is recommended that educators integrate structured IBL strategies and provide teacher training to maximize its benefits in fostering critical thinking, collaboration, and creativity.