Lysosomal size matters.
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Lysosomal size matters.

de Araujo, Mariana E G;Liebscher, Gudrun;Hess, Michael W;Huber, Lukas A;
traffic 2019
281
de-araujo2019lysosomaltraffic

Abstract

Lysosomes are key cellular catabolic centers that also perform fundamental metabolic, signaling and quality control functions. Lysosomes are not static and they respond dynamically to intra- and extracellular stimuli triggering changes in organelle numbers, size and position. Such physical changes have a strong impact on lysosomal activity ultimately influencing cellular homeostasis. In this review, we summarize the current knowledge on lysosomal size regulation, on its physiological role(s) and association to several disease conditions.

Keywords

autophagy ampk fusion lysosome autolysosome borc lamtor pikfyve ptdins(3)p ptdins(3,5)p2 ptdins(4,5)p2 v-atpase endolysosome fission late endosome lysosomal acidification lysosomal reformation lysosomal storage disorders

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DOI:
10.1111/tra.12714

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ID: 68596
Ref Key: de-araujo2019lysosomaltraffic
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68596
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