IL-1 receptor accessory protein is an essential component of the IL-1 receptor
Abstract
The recently described IL-1R accessory protein (IL-1R AcP) interacts with IL-1beta and the IL-1 type-IR (IL-1RI), but an essential requirement for IL-1R AcP in IL-1 signaling in vitro has not been established and its role in vivo has not been examined. In this study, IL-1R AcP-deficient mice and fib …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
female
male
P.H.S.
cell line
Fibroblasts / metabolism
Receptors
embryo
proteins / genetics
tumor necrosis factor-alpha / pharmacology
inbred strains
gene targeting
mammalian
gene expression regulation / immunology
binding
interleukin-1 / genetics
interleukin-6 / biosynthesis
proteins / physiology*
interleukin-1 / pharmacology
interleukin-1 / physiology*
pmid:9820540
e b cullinan
l kwee
m a labow
competitive / immunology
interleukin-1 receptor accessory protein
stem cells
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272385
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