Genetic, biochemical, and clinical features of chronic granulomatous disease
Segal BH;Leto TL;Gallin JI;Malech HL;Holland SM;;
Medicine2000Vol. 79pp. -
209
bh2000medicinegenetic,
Abstract
The reduced nicotinamide dinucleotide phosphate (NADPH) oxidase complex allows phagocytes to rapidly convert O2 to superoxide anion which then generates other antimicrobial reactive oxygen intermediates, such as H2O2, hydroxyl anion, and peroxynitrite anion. Chronic granulomatous disease (CGD) resul …