β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
Abstract
Although deregulation of the Wnt signalling pathway has been implicated in urothelial cell carcinoma (UCC), the functional significance is unknown. To test its importance, we have targeted expression of an activated form of β-catenin to the urothelium of transgenic mice using Cre-Lox technology (Uro …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
Proto-Oncogene Proteins c-akt / metabolism
Cohort Studies
carcinoma
cell proliferation
cell transformation
sequence deletion
beta catenin / metabolism*
phosphatidylinositol 3-kinases / metabolism
hyperplasia / chemically induced
wnt proteins / metabolism
neoplastic / metabolism*
pten phosphohydrolase / metabolism*
pmid:20818428
pmc3044461
doi:10.1038/onc.2010.399
i ahmad
j p morton
o j sansom
adenomatous polyposis coli protein / genetics
papillary / metabolism*
proto-oncogene proteins c-akt / analysis
tor serine-threonine kinases / metabolism
urinary bladder / metabolism
urinary bladder neoplasms / chemically induced*
urothelium / metabolism
Citation
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271483
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