A new secreted protein that binds to Wnt proteins and inhibits their activities

A new secreted protein that binds to Wnt proteins and inhibits their activities

Hsieh JC;Kodjabachian L;Rebbert ML;Rattner A;Smallwood PM;Samos CH;Nusse R;Dawid IB;Nathans J;;
Nature 1999 Vol. 398 pp. -
293
jc1999naturea

Abstract

The Wnt proteins constitute a large family of extracellular signalling molecules that are found throughout the animal kingdom and are important for a wide variety of normal and pathological developmental processes. Here we describe Wnt-inhibitory factor-1 (WIF-1), a secreted protein that binds to Wn …

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