Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice
Abstract
T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) was inhibitory to four strains of avian H5N1 influenza virus in MDCK cells, with the 90% effective concentrations ranging from 1.3 to 7.7 microM, as determined by a virus yield reduction assay. The efficacy was less than that exerted by oseltamivir ca …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
N.I.H.
Extramural
Comparative Study
Cells
Cultured
Inbred BALB C
Viral
Survival Analysis
lung / pathology
antiviral agents / administration & dosage
antiviral agents / therapeutic use*
influenza
human / drug therapy*
cytopathogenic effect
virus replication / drug effects
oxygen / blood
influenza a virus
lung / virology
human / virology
oseltamivir / therapeutic use
human / pathology
pmid:17194832
pmc1803113
doi:10.1128/aac.01051-06
robert w sidwell
dale l barnard
yousuke furuta
amides / administration & dosage
amides / therapeutic use*
h5n1 subtype*
pyrazines / administration & dosage
pyrazines / therapeutic use*
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270849
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