Fetal programming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female
Abstract
Exposure of female sheep fetuses to excess testosterone (T) during early to midgestation produces postnatal hypergonadotropism manifest as a selective increase in LH. This hypergonadotropism may result from reduced sensitivity to estradiol (E2) negative feedback and/or increased pituitary sensitivit …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
non-u.s. gov't
u.s. gov't
female
male
N.I.H.
Extramural
P.H.S.
luteinizing hormone / metabolism*
sexual maturation / drug effects
testosterone / pharmacology*
feedback
sheep
follicle stimulating hormone / pharmacology*
fetus / drug effects
estradiol / administration & dosage
estradiol / pharmacology*
pmid:15976056
doi:10.1210/en.2005-0322
hirendra n sarma
mohan manikkam
vasantha padmanabhan
drug implants
fetus / physiology*
Citation
ID:
269950
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