High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza
Abstract
Clinical samples from 15 amantadine-treated children were collected serially-before, during, and/or after treatment-and were studied to determine the actual prevalence, timing, and clinical implications of M2 mutational events. After viral RNA extraction and reverse-transcriptase polymerase chain re …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
male
adolescent
Child
Infant
preschool
drug resistance
viral / genetics*
influenza
human / drug therapy*
mutation*
human / virology*
keiko mitamura
yoshihiro kawaoka
pmid:12825171
doi:10.1086/375799
kyoko shiraishi
amantadine / pharmacology
amantadine / therapeutic use*
orthomyxoviridae / drug effects
orthomyxoviridae / genetics*
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269891
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