Mismatch repair genes on chromosomes 2p and 3p account for a major share of hereditary nonpolyposis colorectal cancer families evaluable by linkage
Abstract
Two susceptibility loci for hereditary nonpolyposis colorectal cancer (HNPCC) have been identified, and each contains a mismatch repair gene: MSH2 on chromosome 2p and MLH1 on chromosome 3p. We studied the involvement of these loci in 13 large HNPCC kindreds originating from three different continen …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
adult
female
male
middle aged
P.H.S.
DNA
human
Genetic Markers
mutation
chromosome mapping
chromosomes
pedigree
genetic linkage
pmid:7942843
pmc1918295
m nyström-lahti
r parsons
r fusaro
pair 2*
pair 3*
colorectal neoplasms
hereditary nonpolyposis / blood
hereditary nonpolyposis / genetics*
dna repair / genetics*
satellite / blood
satellite / isolation & purification
lod score
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268767
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