Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis
Abstract
In experimental visceral leishmaniasis, in which the tissue macrophage is the target, in vivo responsiveness to conventional chemotherapy (pentavalent antimony [Sb]) requires a T-cell-dependent mechanism. To determine if this mechanism involves gamma interferon (IFN-gamma)-induced activation and/or …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
u.s. gov't
female
male
Disease Models
Animal
P.H.S.
Liver / pathology
Knockout
interferon-gamma / genetics
enzyme inhibitors / pharmacology
chronic / immunology
amphotericin b / therapeutic use
Chronic / genetics
granulomatous disease
leishmaniasis
visceral / immunology*
pmid:10603400
pmc97133
doi:10.1128/iai.68.1.288-293.2000
h w murray
s delph-etienne
antimony / therapeutic use
antiprotozoal agents / therapeutic use
guanidines / pharmacology
interferon-gamma / deficiency
interferon-gamma / immunology*
visceral / drug therapy*
visceral / pathology
liver / parasitology
macrophages / immunology*
nitric oxide synthase / antagonists & inhibitors
nitric oxide synthase / deficiency
nitric oxide synthase / genetics
nitric oxide synthase type ii
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Citation
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268636
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