Effect of IRT5 probiotics on dry eye in the experimental dry eye mouse model
Abstract
In experimental dry eye model, IRT5 probiotics treatment partially improves experimental dry eye by increasing tear secretion which was associated with and influenced by the change in intestinal microbiome. Also, intestinal microbiome may affect the lacrimal gland through a different mechanism other …
Keywords
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
RNA
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Disease Models
Animal
Ribosomal
tears / physiology
dry eye syndromes / therapy*
oral
probiotics / administration & dosage*
16s
dry eye syndromes / physiopathology
jin suk ryu
mee kum kim
cornea / pathology
pmid:33259525
pmc7707591
doi:10.1371/journal.pone.0243176
jayoon moon
conjunctiva / immunology
conjunctiva / pathology
cornea / immunology
dry eye syndromes / pathology
gastrointestinal microbiome / genetics
goblet cells / pathology
real-time polymerase chain reaction
tumor necrosis factor-alpha / genetics
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267303
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