Suboptimal aminoglycoside dosing in critically ill patients
Abstract
Maximal aminoglycoside (AG) killing requires that the ratio of peak serum concentrations (Cmax) to the minimum inhibitory concentration (MIC) of the pathogen exceeds by > or =10. This has been shown to hasten resolution of infection in the general patient population. It was postulated that critic …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
adult
female
male
N.I.H.
Extramural
adolescent
aged
middle aged
80 and over
Bacterial
anti-bacterial agents / therapeutic use
drug resistance
bacteria / drug effects
microbial sensitivity tests
anti-bacterial agents / administration & dosage*
dose-response relationship
drug
intensive care units
bacterial infections / drug therapy
critical illness
anti-bacterial agents / pharmacokinetics*
gentamicins / therapeutic use
pmid:19057371
doi:10.1097/ftd.0b013e31818b6b2f
rhonda s rea
blair capitano
howard lee
anti-bacterial agents / blood
gentamicins / administration & dosage*
gentamicins / blood
gentamicins / pharmacokinetics*
tobramycin / administration & dosage*
tobramycin / blood
tobramycin / pharmacokinetics*
tobramycin / therapeutic use
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266496
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