Life satisfaction is a subjective construct that varies according to gender, education level, age, income, marital status, and other demographic factors. Life satisfaction is an important issue among middle-aged women. They face various responsibilities, roles and expectation at this age. The objective of this article is to identify the differences in life satisfaction among middle-aged Malay women from different educational level, marital status, career and income. This study applied a survey technique, which is a set of questionnaire which consisted of socio-demographic scale and life satisfaction scale (based on Life Satisfaction Index - Short Form by Barrette and Murk, 2006). Simple random sampling and purposive sampling have been used to obtain the responses. A total of 410 middle-aged career women in Hulu Langat, Selangor have participated in this study. The finding showed that life satisfactions among middle-aged women are different depending on their marital status, career and income. This was based on the result of ANOVA. Single women and widower who are working in private sector and of low-income level reported to have the lowest life satisfaction. This finding may provide input to the planning of programs to enhance the well-being and life satisfaction among middle aged career women.