Women entrepreneurship benefit from a process of expansion all over the world. Business established and developed by women are an important source of wealth and improved living standards in many countries. Even though women represent 46% of Europe's working population, which means in theory that trend of this type entrepreneurship can only go upward, however entrepreneurship is still considered an activity for men. Entrepreneurship has an active role in employment, economic development and quality of life, constituting a dynamic part of any developed economy. Supporting women in their involvement in setting up new start-ups and small business and unlock their potential is an important part of government actions to foster entrepreneurial activities. Global Entrepreneurship Monitor (GEM) study found out that economies of Eastern European countries are in poor condition in terms of women's participation in entrepreneurial activity. Romania is no exception. This paper analyze women entrepreneurship in the poorest region of Romania, North East region, through an empirical survey but provide also some insights on overall Romanian situation based on National Trade Register Office data.