Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective
Abstract
While the link between obesity and type 2 diabetes is clear on an epidemiological level, the underlying mechanism linking these two common disorders is not as clearly understood. One hypothesis linking obesity to type 2 diabetes is the adipose tissue expandability hypothesis. The adipose tissue expa …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
review
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
Adipocytes / metabolism
diabetes mellitus / metabolism
Adipose Tissue / metabolism*
cell differentiation
liver / metabolism
biological
lipid metabolism*
neovascularization
pathologic / metabolism
insulin resistance
sam virtue
antonio vidal-puig
pmid:20056169
doi:10.1016/j.bbalip.2009.12.006
allostasis / physiology*
insulin-secreting cells / metabolism
metabolic syndrome / metabolism*
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119267
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