National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't u.s. gov't adult female male Depressive Disorder Major / psychology adolescent aged middle aged Comparative Study P.H.S. Clinical Trial Randomized Controlled Trial Multicenter Study severity of illness index Psychometrics chronic disease madhukar h trivedi a john rush major / therapy pmid:12946886 doi:10.1016/s0006-3223(02)01866-8 martin b keller major / diagnosis* psychiatric status rating scales / standards* self-assessment