Safety and immunogenicity of a purified F protein respiratory syncytial virus (PFP-2) vaccine in seropositive children with bronchopulmonary dysplasia
Abstract
Respiratory syncytial virus (RSV) causes serious respiratory illness in preterm children with bronchopulmonary dysplasia. In a prospective randomized placebo-controlled trial, 21 children received one dose of PFP-2 (purified fusion [F] protein) vaccine or influenza vaccine (placebo). Children were f …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
Child
Infant
Prospective Studies
newborn
P.H.S.
preschool
Clinical Trial
Randomized Controlled Trial
Antibodies
Double-Blind Method
Viral / analysis
neutralization tests
respiratory syncytial virus infections / prevention & control*
viral vaccines / adverse effects*
hospitalization
viral / immunology
hn protein*
viral envelope proteins
seasons
respiratory syncytial virus infections / immunology*
immunoglobulin g / analysis
immunoglobulin g / immunology
viral proteins / immunology*
viral vaccines / immunology*
viral vaccines / administration & dosage
pmid:9466539
doi:10.1086/517377
j r groothuis
s j king
e a simoes
bronchopulmonary dysplasia / virology*
influenza vaccines / administration & dosage
influenza vaccines / adverse effects
influenza vaccines / immunology
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117237
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