Brain neuronal degeneration caused by episodic alcohol intoxication in rats: effects of nimodipine, 6,7-dinitro-quinoxaline-2,3-dione, and MK-801
Abstract
Rats repeatedly intoxicated with alcohol (ethanol, three times daily) over a 4-day period display neuronal degeneration in the dentate gyrus; entorhinal, piriform, insular, orbital, and perirhinal cortices; and in the olfactory nerve fibers and terminals in the olfactory bulb. Postulating a role for …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
male
Alcoholic Intoxication / pathology*
Brain / drug effects*
Drug Administration Schedule
Rats
Sprague-Dawley
e j neafsey
dentate gyrus / pathology
dose-response relationship
drug
neuroprotective agents / pharmacology*
neurons / drug effects
nerve degeneration / pathology
neurons / pathology
brain / pathology
pmid:9514310
t d corso
h m mostafa
calcium channel blockers / pharmacology*
dentate gyrus / drug effects
dizocilpine maleate / pharmacology*
excitatory amino acid antagonists / pharmacology*
nerve degeneration / chemically induced*
nimodipine / pharmacology*
quinoxalines / pharmacology*
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115335
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