Research article
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Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies
Journal of Virology, vol. 66, no. 2, pp. –, 1992
Abstract
It was previously demonstrated that the vaccinia virus recombinants expressing the respiratory syncytial virus (RSV) F, G, or M2 (also designated as 22K) protein (Vac-F, Vac-G, or Vac-M2, respectively) induced almost complete resistance to RSV challenge in BALB/c mice. In the present study, we sough …
Keywords
- National Center for Biotechnology Information
- NCBI
- NLM
- MEDLINE
- genetic
- Mice
- animals
- humans
- pubmed abstract
- nih
- national institutes of health
- national library of medicine
- female
- Antibodies
- Antigens
- cell line
- recombination
- Inbred BALB C
- respiratory syncytial viruses / immunology*
- respirovirus infections / immunology
- b r murphy
- hn protein*
- vaccinia virus / genetics
- viral envelope proteins
- viral proteins*
- viral vaccines*
- viral / immunology*
- m connors
- respiratory syncytial viruses / genetics
- respirovirus infections / prevention & control
- t-lymphocyte subsets / immunology*
- viral / genetics
- pmid:1731105
- pmc240842
- doi:10.1128/jvi.66.2.1277-1281.1992
- a b kulkarni
- cd4 antigens / immunology
- cd4-cd8 ratio
- cd8 antigens / immunology*
- immunization*
- lymphocyte depletion
- vaccinia virus / immunology*
How to cite
Connors M; Kulkarni AB; Collins PL; Firestone CY; Holmes KL; Morse HC; Murphy BR. (1992). Resistance to respiratory syncytial virus (RSV) challenge induced by infection with a vaccinia virus recombinant expressing the RSV M2 protein (Vac-M2) is mediated by CD8+ T cells, while that induced by Vac-F or Vac-G recombinants is mediated by antibodies. Journal of Virology, 66(2), –. http://www.ncbi.nlm.nih.gov/pubmed/1731105
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