Adrenal hyperandrogenism is induced by fetal androgen excess in a rhesus monkey model of polycystic ovary syndrome
Abstract
Enhanced basal and ACTH-stimulated adrenal androgen levels in PA female monkeys may reflect up-regulation of 17,20 lyase activity in the adrenal zona reticularis, causing adrenal androgen excess comparable with that found in PCOS women with adrenal androgen excess. These findings open the possibilit …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
pregnancy
research support
female
N.I.H.
Extramural
david h abbott
Polycystic Ovary Syndrome / metabolism*
macaca mulatta
pmid:16174719
pmc1350929
doi:10.1210/jc.2005-0691
rao zhou
ian m bird
adrenal glands / metabolism*
adrenocorticotropic hormone / pharmacology
androgens / metabolism*
area under curve
dehydroepiandrosterone / blood
dexamethasone / pharmacology
fetus / metabolism*
hormones / blood
hyperandrogenism / etiology*
hyperandrogenism / metabolism*
prenatal exposure delayed effects*
steroids / blood
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111508
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