Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction
Abstract
Even though ferrets are one of the principal animal models for influenza pathogenesis, the lack of suitable immunological reagents has so far limited their use in host response studies. Using recently established real-time PCR assays for a panel of ferret cytokines, we analyzed the local ferret immu …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Body Weight
Molecular Sequence Data
severity of illness index
lung / pathology
orthomyxoviridae infections / immunology*
gene expression profiling
seasons
influenza a virus
lung / virology
ferrets
h1n1 subtype / immunology*
orthomyxoviridae infections / virology
body temperature
interleukin-6 / genetics
pmid:18420248
doi:10.1016/j.virol.2008.02.035
nicholas svitek
penny a rudd
veronika von messling
h1n1 subtype / growth & development
h3n2 subtype / growth & development
h3n2 subtype / immunology*
interferons / genetics
interferons / immunology*
interleukin-6 / immunology*
interleukin-8 / genetics
interleukin-8 / immunology
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284139
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