A strategy to incorporate prior knowledge into correlation network cutoff selection
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A strategy to incorporate prior knowledge into correlation network cutoff selection

Benedetti, Elisa;Pučić-Baković, Maja;Keser, Toma;Gerstner, Nathalie;Büyüközkan, Mustafa;Štambuk, Tamara;Selman, Maurice H. J.;Rudan, Igor;Polašek, Ozren;Hayward, Caroline;Al-Amin, Hassen;Suhre, Karsten;Kastenmüller, Gabi;Lauc, Gordan;Krumsiek, Jan;
Nature communications 2020 Vol. 11 pp. 1-12
24
benedetti2020anature

Abstract

Correlation network inference is typically based on the significance of the correlation coefficients, but this procedure is not guaranteed to capture biological mechanisms. Here, the authors develop a cutoff selection algorithm that maximizes the overlap between inferred networks and prior knowledge.

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Education Medicine (General) Science business management. industrial management computer engineering. computer hardware electronic computers. computer science ethics medical philosophy. medical ethics

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https://doi.org/10.1038/s41467-020-18675-3

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