Colic is a multifaceted ailment with a wide range of therapeutic strategies. Infantile colic is often regarded as the most excruciating agony a newborn has ever experienced. Inconsolable crying, fussing, irritability, and abdominal discomfort are some of the classical presentations of infantile colic. Infantile colic is associated with various gastrointestinal conditions as well as behavioral and neurodevelopmental complications. Nevertheless, a variation in the microbial composition of the gut is a consistent finding in infantile colic. Although there is inadequate data to support successful treatment for infantile colic, a few frequently applied pharmaceutical interventions, such as dicyclomine, simethicone, and cimetropium have not been recommended based on contemporary research. Lifestyle modifications such as lactase and probiotics supplements have indicated benefits in treating colic, but additional control studies will be a prerequisite to assess their efficacy. This review provided in-depth information on colic, its pathophysiology, the therapeutic potential of plants with spasmolytic effects, as well as their possible mechanisms of action. Furthermore, the study showed that active compounds in numerous traditionally used plants have a substantial anti-spasmodic activity that is safer and more effective than currently accessible synthetic medications.