Identification and characterization of a novel botulinum neurotoxin
Abstract
Botulinum neurotoxins are known to have seven serotypes (BoNT/A-G). Here we report a new BoNT serotype, tentatively named BoNT/X, which has the lowest sequence identity with other BoNTs and is not recognized by antisera against known BoNTs. Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Molecular
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
models
research support
non-u.s. gov't
N.I.H.
Extramural
amino acid motifs
amino acid sequence
sequence alignment
botulinum toxins / metabolism*
pmid:28770820
pmc5543303
doi:10.1038/ncomms14130
sicai zhang
geoffrey masuyer
pål stenmark
botulinum toxins / chemistry
botulinum toxins / genetics
botulinum toxins / toxicity
botulism / genetics
botulism / metabolism
botulism / microbiology*
clostridium botulinum / enzymology*
clostridium botulinum / genetics
neurotoxins / chemistry
neurotoxins / genetics
neurotoxins / metabolism*
neurotoxins / toxicity
r-snare proteins / chemistry
r-snare proteins / genetics
r-snare proteins / metabolism
vesicle-associated membrane protein 2 / chemistry
vesicle-associated membrane protein 2 / genetics
vesicle-associated membrane protein 2 / metabolism
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274522
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