A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes
Abstract
The activation of maturation-promoting factor (MPF) is required for G(2)/M progression in eukaryotic cells. Xenopus oocytes are arrested in G(2) and are induced to enter M phase of meiosis by progesterone stimulation. This process is known as meiotic maturation and requires the translation of specif …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Molecular
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
amino acid sequence
cell line
DNA
Base Sequence
Molecular Sequence Data
complementary
cloning
rabbits
cell cycle proteins / genetics
cell cycle proteins / metabolism*
oocytes / drug effects
progesterone / pharmacology
xenopus proteins*
xenopus
oocytes / cytology
enzyme activation
cdc2 protein kinase / metabolism*
mitosis*
cycloheximide / pharmacology
cyclin b / metabolism
maturation-promoting factor / metabolism
pmid:10465793
pmc316955
doi:10.1101/gad.13.16.2177
i ferby
m blazquez
a r nebreda
g2 phase*
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274011
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