Enteric infections, diarrhea, and their impact on function and development
Abstract
Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration caused by infection with an enteric pathogen, but it has not changed the morbidity caused by such infections. This Review focuses on the interactions between enteric pathogens and human genetic determinants that alter intestinal function and inflammation and profoundly impair human health and development. We also discuss specific implications for novel approaches to interventions that are now opened by our rapidly growing molecular understanding.
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273560
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0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
273560
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10.1172/jci34005
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Scimatic Chain (ID: 481)
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