Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)
Abstract
Transcription of the low density lipoprotein receptor gene and other sterol-regulated genes is stimulated by sterol regulatory element-binding protein-1 (SREBP-1), a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. Human SREBP-1 is synthesized as an 1147-amino acid precursor th …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
gene expression regulation
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
amino acid sequence
sequence alignment
Comparative Study
P.H.S.
DNA-Binding Proteins / metabolism*
Nuclear Proteins / metabolism*
Transcription Factors / metabolism*
Molecular Sequence Data
sequence homology
amino acid
cricetinae
solubility
structure-activity relationship
mutagenesis
sterol regulatory element binding protein 1
nuclear proteins / chemistry
m s brown
ccaat-enhancer-binding proteins*
site-directed
cell compartmentation
j yang
membrane proteins / metabolism*
r sato
pmid:8006035
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271707
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