National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Inbred C57BL RNA animals pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't female male N.I.H. Extramural Obesity / metabolism phenotype recombination Body Weight Receptors Genotype Blood Glucose / metabolism Crosses time factors messenger / metabolism adipose tissue / metabolism analysis of variance neurons / metabolism blotting western signal transduction diet* southern genetic predisposition to disease silver staining homeostasis leptin / metabolism insulin-like growth factor i / metabolism dna / metabolism body composition obesity / genetics* gene deletion magnetic resonance spectroscopy recombinant proteins / genetics alleles recombinant proteins / metabolism heterozygote joel k elmquist animal feed ghrelin pmid:16322794 pmc1297251 doi:10.1172/jci26002 jeffrey m zigman yoshihide nakano hyperglycemia / metabolism peptide hormones / chemistry peptide hormones / physiology* g-protein-coupled / genetics* g-protein-coupled / physiology*