Daratumumab plus pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone in previously treated multiple myeloma (APOLLO): an open-label, randomised, phase 3 trial

Daratumumab plus pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone in previously treated multiple myeloma (APOLLO): an open-label, randomised, phase 3 trial

Dimopoulos MA;Terpos E;Boccadoro M;Delimpasi S;Beksac M;Katodritou E;Moreau P;Baldini L;Symeonidis A;Bila J;Oriol A;Mateos MV;Einsele H;Orfanidis I;Ahmadi T;Ukropec J;Kampfenkel T;Schecter JM;Qiu Y;Amin H;Vermeulen J;Carson R;Sonneveld P; ;;
The Lancet. Oncology 2021 Vol. 22 pp. -
351
ma2021thedaratumumab

Abstract

European Myeloma Network and Janssen Research and Development.

Keywords

National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male aged middle aged Clinical Trial Phase III Randomized Controlled Trial Antibodies Proportional Hazards Models neutropenia / chemically induced monoclonal / adverse effects neoplasm recurrence local / pathology antineoplastic combined chemotherapy protocols / adverse effects antineoplastic combined chemotherapy protocols / administration & dosage neutropenia / pathology Progression-Free Survival initials='g' affs=[] is_editor=false suffix=none equal_contrib=false) initials='j' initials='a' initials='h' initials='ma' initials='b' initials='n' initials='p' initials='l' initials='d' affs=[]) initials='s' initials='m' initials='f' initials='c' author(firstnames='philippe' author(firstnames='ali' initials='r' author(firstnames='roberto' initials='e' initials='t' author(firstnames='stefan' author(firstnames='hans' author(firstnames='mario' author(firstnames='javier' author(firstnames='xavier' initials='x' author(firstnames='juan josé' initials='jj' author(firstnames='sebastián' author(firstnames='carmen' author(firstnames='pieter' initials='mc' initials='mv' equal_contrib=false)] author(firstnames='brian' meletios a dimopoulos lastname='doyen' lastname='meuleman' lastname='wu' lastname='engelhardt' lastname='goldschmidt' lastname='knop' lastname='foa' lastname='zweegman' multiple myeloma / drug therapy* thalidomide / administration & dosage thalidomide / adverse effects thalidomide / analogs & derivatives* pmid:34087126 doi:10.1016/s1470-2045(21)00128-5 evangelos terpos collabauthor(name='apollo trial investigators' investigators=[author(firstnames='adrian' lastname='alegre amor' author(firstnames='luca' lastname='baldini' author(firstnames='meral' lastname='beksac' author(firstnames='angelo' lastname='belotti' author(firstnames='lotfi' lastname='benboubker' author(firstnames='britta' lastname='besemer' author(firstnames='sevgi' lastname='besisik' author(firstnames='jelena' lastname='bila' lastname='boccadoro' author(firstnames='michele' lastname='cavo' lastname='de la rubia comos' author(firstnames='sosana' lastname='delimpasi' author(firstnames='meletios a' lastname='dimopoulos' author(firstnames='chantal' author(firstnames='dominik' lastname='dytfeld' author(firstnames='monika' author(firstnames='thierry' lastname='facon' author(firstnames='hartmut' lastname='grosicki' author(firstnames='roman' lastname='hajek' author(firstnames='guner' lastname='hayri ozsan' author(firstnames='cyrille' lastname='hulin' lastname='iversen' author(firstnames='lionel' lastname='karlin' author(firstnames='eirini' lastname='katodritou' author(firstnames='marie-christine' lastname='kyrtsonis' lastname='lahuerta' lastname='leleu' lastname='martinez chamorro' author(firstnames='maría-victoria' lastname='mateos manteca' author(firstnames='nathalie' author(firstnames='monique' lastname='minnema' lastname='moreau' author(firstnames='massino' lastname='offidani' author(firstnames='albert' lastname='oriol rocafiguera' author(firstnames='mustafa' lastname='pehlivan' author(firstnames='ludek' lastname='pour' author(firstnames='henk th j' lastname='roerdink' initials='htj' author(firstnames='laura' lastname='rosinol dacsh' lastname='salwender' lastname='sonneveld' author(firstnames='anargyros' lastname='symeonidis' author(firstnames='charlotte' lastname='toftmann hansen' author(firstnames='tulin' lastname='tuglular' lastname='unal' author(firstnames='philip' lastname='vlummens' author(firstnames='filiz' lastname='vural' author(firstnames='ka lung' initials='kl' author(firstnames='sonja' monoclonal / administration & dosage* dexamethasone / administration & dosage* dexamethasone / adverse effects multiple myeloma / pathology local / drug therapy

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