National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female protein biosynthesis P.H.S. Rats Knockout Organ Specificity in vitro techniques transgenic neurons / metabolism hypothalamus / metabolism* paraventricular hypothalamic nucleus / drug effects agouti-related protein ghrelin hypothalamus / drug effects intercellular signaling peptides and proteins luminescent proteins / biosynthesis neurons / cytology pmid:12597862 doi:10.1016/s0896-6273(03)00063-1 michael a cowley roy g smith tamas l horvath central nervous system / cytology central nervous system / metabolism* corticotropin-releasing hormone / biosynthesis energy metabolism / physiology* homeostasis / physiology* hypothalamus / cytology nerve net / metabolism* neuropeptide y / biosynthesis paraventricular hypothalamic nucleus / metabolism patch-clamp techniques peptide hormones / metabolism* peptide hormones / pharmacology presynaptic terminals / metabolism pro-opiomelanocortin / biosynthesis protein binding / physiology proteins*