Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation
Abstract
Bone morphogenetic proteins (BMPs) play important roles in regulating lung development and function although the endogenous regulatory effects of BMP signaling are still controversial. We found that BMP type I receptor Alk3 is expressed predominantly in airway epithelial cells during development. Th …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
gene expression regulation
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
female
N.I.H.
Extramural
newborn
Knockout
Organ Specificity
developmental
transgenic
signal transduction
lung / metabolism
bone morphogenetic protein receptors
lung / embryology
pmid:18258849
pmc2258256
doi:10.2353/ajpath.2008.070286
jianping sun
hui chen
wei shi
type i / genetics*
type i / metabolism
bone morphogenetic proteins / metabolism*
lung / abnormalities*
organogenesis / genetics
respiratory insufficiency / embryology
respiratory insufficiency / metabolism*
respiratory mucosa / embryology
respiratory mucosa / metabolism*
Access
Citation
ID:
269560
References
Blockchain Verification
Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
269560
Unique Identifier:
Network:
Scimatic Chain (ID: 481)
Loading...
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
Creates 1,000,000 NFT tokens for this article
Token Features:
- ERC-1155 Standard NFT
- 1 Million Supply per Article
- Transferable via MetaMask
- Permanent Blockchain Record
Scan with Saymatik Web3.0 Wallet