Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism
Abstract
The process of transcriptional activation in eukaryotes by site-specific DNA-binding proteins is a key step in gene regulation. Here we have examined the properties of four distinct activator domains of the human transcription factor Sp1. In vivo transient cotransfection assays with Sp1 show that te …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
animals
pubmed abstract
nih
national institutes of health
national library of medicine
genetic*
plasmids
Base Sequence
Molecular Sequence Data
Gene Expression Regulation*
Promoter Regions
transcription
transfection
solutions
dna / metabolism
mutagenesis
sp1 transcription factor / metabolism*
e pascal
r tjian
pmid:1885006
doi:10.1101/gad.5.9.1646
drosophila / cytology
drosophila / genetics
sp1 transcription factor / genetics
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269065
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