Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
Hirschfeld M;Ma Y;Weis JH;Vogel SN;Weis JJ;;
Journal of immunology (Baltimore, Md. : 1950)2000Vol. 165pp. -
348
m2000journalcutting
Abstract
Toll-like receptor (TLR) 2 has recently been associated with cellular responses to numerous microbial products, including LPS and bacterial lipoproteins. However, many preparations of LPS contain low concentrations of highly bioactive contaminants described previously as "endotoxin protein," suggest …