Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy*
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Altered circulating leukocytes and their chemokines in a clinical trial of therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy*

Jenkins DD;Lee T;Chiuzan C;Perkel JK;Rollins LG;Wagner CL;Katikaneni LP;Bass WT;Kaufman DA;Horgan MJ;Laungani S;Givelichian LM;Sankaran K;Yager JY;Martin R;;
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2013 Vol. 14 pp. -
310
dd2013pediatricaltered

Abstract

Our data are consistent with chemokine-associated systemic immunosuppression with hypothermia treatment. In hypothermic neonates, persistence of lower leukocyte counts after rewarming is observed in infants with more severe CNS injury.

Keywords

National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't female male N.I.H. Extramural Infant newborn Randomized Controlled Trial Multicenter Study time factors intensive care units leukocyte count hypoxia-ischemia hypothermia neonatal pmid:23897243 doi:10.1097/pcc.0b013e3182975cc9 dorothea d jenkins timothy lee renee martin chemokines / blood* induced* brain / blood* brain / therapy* leukocytes / physiology*

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