the association of thyroid disease and oral lichen planus: a literature review and meta-analysis
Abstract
BackgroundThe objective of this study was to systemically evaluate the association between oral lichen planus (OLP) and thyroid disease.MethodEleven electronic databases were searched for any clinical study published up until August 2016 that explored an association between OLP and thyroid disease, complemented with manual searching. The titles and abstracts of all studies identified from the electronic searches were then assessed independently to determine inclusion of the study. The population of interest was patients with OLP, and the exposure was the presence of thyroid disease in OLP patients. Statistical analyses were conducted using Review Manager 5.2. The odds ratios (OR) and 95% confidence intervals (CIs) were calculated to evaluate the association between OLP and thyroid disease.ResultsEight studies were included for review, and of these, four case-control studies were included in the final meta-analysis. The mean Newcastle–Ottawa Scale score evaluating the methodological quality of the four studies was 6.5. The OR was 2.10 (95% CI: 1.47–3.01), indicating a statistically significant difference in the prevalence of thyroid disease between the OLP and control groups. Heterogeneity was satisfactory (I2 = 0%, <25%). An approximately symmetrical funnel plot suggested no obvious publication bias. Two articles showed a higher correlation between OLP and hypothyroidism (OR 1.83, 95% CI: 1.16–2.89), with satisfactory heterogeneity (I2 = 0%, <25%).ConclusionThis meta-analysis indicated a significantly high prevalence of thyroid disease among OLP patients compared with controls, suggesting that routine screening for thyroid disease could be beneficial to OLP patients. However, due to the small number of studies included, further studies are needed to confirm the results.
Keywords
stroke
obesity
oxidative stress
infants
aging process
pathogenesis
caregivers
chlorophyll
parkinson's disease
photosynthesis
ultimatum game
strength
salt stress
traditional chinese medicine
seed germination
growth and development
cell transplantation
hypothyroidism
forage quality
arabidopsis
face
pvn
aerobic exercise
cardiovascular function
thyroid disease
aspergillus aculeatus
visual field
neuronal apoptosis
abscisic acid (aba)
spasticity
oral lichen planus
pharmacology
clinical endocrinology
diseases of the nervous system
neuropsychiatry
biological psychiatry
meta-analysisdiseases of the endocrine glands
gabaergic neuronsneurosciences
Citation
ID:
243489
References
Blockchain Verification
Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
243489
Unique Identifier:
10.3389/fendo.2017.00310
Network:
Scimatic Chain (ID: 481)
Loading...
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
Creates 1,000,000 NFT tokens for this article
Token Features:
- ERC-1155 Standard NFT
- 1 Million Supply per Article
- Transferable via MetaMask
- Permanent Blockchain Record
Scan with Saymatik Web3.0 Wallet