validação de método espectrofotométrico na região do uv para quantificação de famotidina em cápsulas validation of an uv spectrophotometric method for quantification of famotidine in capsules
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validação de método espectrofotométrico na região do uv para quantificação de famotidina em cápsulas validation of an uv spectrophotometric method for quantification of famotidine in capsules

;Lívia Botacini Favoretto;Juliana Maria Oliveira Souza;Rudy Bonfilio;Roberta de Cássia Pimentel Azevedo;Magali Benjamim de Araújo
greece and rome 2010 Vol. 33 pp. 1585-1589
176
favoretto2010qumicavalidao

Abstract

This work describes the validation of a method for quantification of famotidine in capsules by UV spectrophotometry using as solvents buffer solution at pH 2.5 and buffer solution at pH 4.5. The results show that the method is practical, selective, accurate, precise and linear from 10.0 to 25.0 µg/mL of famotidine in both solvents. However, a variance analysis showed a lower mean percentage of famotidine when buffer at pH 2.5 is used. This effect was attributed to the instability of famotidine in acidic media. Therefore, the use of pH 4.5 buffer was considered suitable for analysis of famotidine in capsules.

Keywords

validation uv spectrophotometrychemistry

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DOI:
10.1590/S0100-40422010000700028
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