Background: South Africa is challenged with high levels of unemployment, comprising many people with low levels of education and also individuals who have never held a job before. Despite having many vulnerable participants, interventions aimed at the unemployed generally exclude psychosocial training and are methodologically weak. Aim: The JOBS programme, a scientifically sound intervention, has been developed specifically to help people affected by unemployment to cope with the psychological effects. As a means of applying such a programme in South Africa, this study aimed to develop a framework based on the insights gained on the implementation and evaluation of the JOBS programme. Methods: The study comprised a systematic review of literature regarding the JOBS intervention and its derivatives (n = 34). Results: The results revealed that populations similar to the unemployed in South Africa had benefitted significantly regarding re-employment and mental health outcomes. Conclusion: Suggestions derived from the literature included aiming the programme at the most vulnerable unemployed in South Africa: the youth and long-term unemployed. Furthermore, expanding the programme by adding an entrepreneurial component may yield positive results, considering the lack of employment opportunities in South Africa.