Investigation into the selection frequency of resistant mutants and the bacterial kill rate by levofloxacin and ciprofloxacin in non-mucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients
Abstract
The frequency by which resistant Pseudomonas aeruginosa strains could be selected was compared for two antibiotics, levofloxacin and ciprofloxacin. Seven distinct strains were cultured on plates containing 1x, 2x, 4x and 8x the minimum inhibitory concentration (MIC) of the antibiotic under investiga …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
adult
genetic*
mutation
drug resistance
multiple
bacterial*
time factors
microbial sensitivity tests
pseudomonas aeruginosa / drug effects*
dose-response relationship
drug
ciprofloxacin / pharmacology*
levofloxacin*
ofloxacin / pharmacology*
pseudomonas infections / microbiology
selection
anti-infective agents / pharmacology
t gillespie
r g masterton
pmid:12007845
doi:10.1016/s0924-8579(02)00017-1
cystic fibrosis / microbiology*
pseudomonas aeruginosa / genetics
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Citation
ID:
119129
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