Emergence of teicoplanin resistance during therapy of Staphylococcus aureus endocarditis
Abstract
Serial isolates of Staphylococcus aureus showing two- to eightfold increases in teicoplanin minimum inhibitory concentrations (MICs) and twofold or less increases in MICs of other glycopeptides were recovered from the blood of a patient with endocarditis in whom drug therapy was unsuccessful. Compar …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
adult
female
male
case reports
DNA
Bacterial / analysis
mutation
drug resistance
microbial sensitivity tests
staphylococcal infections / microbiology
microbial
staphylococcus aureus / drug effects*
anti-bacterial agents / pharmacology
staphylococcus aureus / genetics
anti-bacterial agents / therapeutic use*
bacterial / microbiology
staphylococcal infections / drug therapy*
bacterial / drug therapy*
rabbits
staphylococcus aureus / classification
endocarditis
s a lerner
pmid:2141343
doi:10.1093/infdis/162.1.103
g w kaatz
s m seo
glycopeptides / pharmacology
glycopeptides / therapeutic use
membrane proteins / analysis
r factors
teicoplanin
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Citation
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117646
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