Development of a New Type of Recombinant Hyaluronidase Using a Hexahistidine; Possibilities and Challenges in Commercialization
Abstract
Hyaluronidases enhance therapeutic drug transport by breaking down the hyaluronan barrier to lymphatic and capillary vessels, facilitating their tissue absorption. Commercially available hyaluronidases are bovine in origin; however, they pose risks such as bovine spongiform encephalopathy. The prese …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Molecular
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
cattle
Temperature
cloning
hydrogen-ion concentration
pmid:31370115
doi:10.4014/jmb.1905.05049
chaeri park
yun-kyoung song
ekyune kim
cell adhesion molecules / metabolism
enzyme stability
hek293 cells
histidine / metabolism*
hyaluronic acid / metabolism
hyaluronoglucosaminidase / genetics*
hyaluronoglucosaminidase / isolation & purification
hyaluronoglucosaminidase / metabolism*
oligopeptides / metabolism*
recombinant proteins*
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117547
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